网页2021/04/08 · 7EL5. PubMed Abstract: Sizzled (Szl) is both a secreted frizzled related protein (sFRP) and a naturally occurring inhibitor of the zinc metalloproteinase bone morphogenetic protein-1 (BMP-1), a key regulator of extracellular matrix assembly and growth factor activation. Here we present a new crystal structure for Szl which differs from
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网页2006/03/05 · Here, we describe a previously unrecognized role for a secreted Frizzled-related protein. Nature Cell Biology - Sizzled controls dorso-ventral polarity by repressing cleavage of the Chordin
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网页Function [ edit] Secreted frizzled-related protein 1 (SFRP1) is a member of the SFRP family that contains a cysteine -rich domain homologous to the putative Wnt-binding site of
网页2017/09/29 · The Wnt-signaling pathway is crucial to cell proliferation, differentiation, and migration. The secreted Frizzled-related proteins (sFRPs) represent the largest family of secreted Wnt inhibitors. However, their function in antagonizing Wnt signaling has remained somewhat controversial. Here, we repo
网页2017/09/29 · The overall structure of Sizzled resembles the arabic numeral “8,” and the elongated shape has a length of 75 Å and a maximal width of 50 Å (Fig. 1B).The N-terminal CRD (residues 24–142) packs onto the tip of the C
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